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bisulfite conversion controls  (EpigenDx)

 
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    EpigenDx bisulfite conversion controls
    Bisulfite Conversion Controls, supplied by EpigenDx, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bisulfite conversion controls/product/EpigenDx
    Average 90 stars, based on 1 article reviews
    bisulfite conversion controls - by Bioz Stars, 2026-03
    90/100 stars

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    bisulfite conversion control probes  (Illumina Inc)
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    Illumina Inc bisulfite conversion control probes
    Association between cytosine methylation changes and interstitial fibrosis. a Manhattan plot of Interstitial Fibrosis associated methylation changes. The x -axis represents the genomic location of the probe, while the y -axis is the negative base 10 log of the p -value. (The association between the methylation level of 321,473 <t>probes</t> and kidney fibrosis was studied using a linear regression models adjusted for age, gender, race, diabetes, hypertension, batch, <t>bisulfite</t> <t>conversion,</t> and degree of lymphocytic infiltrate on histology. The threshold for genome-wide significance was set at p -value FDR < 0.05 as indicated by the horizontal magenta line). b Volcano plot depicting the association between Interstitial Fibrosis and methylation changes. The x -axis represents the Pearson correlation coefficient of each probe with Interstitial Fibrosis. The y -axis is the negative base 10 log of the p -value each probe associated with Interstitial Fibrosis
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    Association between cytosine methylation changes and interstitial fibrosis. a Manhattan plot of Interstitial Fibrosis associated methylation changes. The x -axis represents the genomic location of the probe, while the y -axis is the negative base 10 log of the p -value. (The association between the methylation level of 321,473 probes and kidney fibrosis was studied using a linear regression models adjusted for age, gender, race, diabetes, hypertension, batch, bisulfite conversion, and degree of lymphocytic infiltrate on histology. The threshold for genome-wide significance was set at p -value FDR < 0.05 as indicated by the horizontal magenta line). b Volcano plot depicting the association between Interstitial Fibrosis and methylation changes. The x -axis represents the Pearson correlation coefficient of each probe with Interstitial Fibrosis. The y -axis is the negative base 10 log of the p -value each probe associated with Interstitial Fibrosis

    Journal: Nature Communications

    Article Title: Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

    doi: 10.1038/s41467-019-10378-8

    Figure Lengend Snippet: Association between cytosine methylation changes and interstitial fibrosis. a Manhattan plot of Interstitial Fibrosis associated methylation changes. The x -axis represents the genomic location of the probe, while the y -axis is the negative base 10 log of the p -value. (The association between the methylation level of 321,473 probes and kidney fibrosis was studied using a linear regression models adjusted for age, gender, race, diabetes, hypertension, batch, bisulfite conversion, and degree of lymphocytic infiltrate on histology. The threshold for genome-wide significance was set at p -value FDR < 0.05 as indicated by the horizontal magenta line). b Volcano plot depicting the association between Interstitial Fibrosis and methylation changes. The x -axis represents the Pearson correlation coefficient of each probe with Interstitial Fibrosis. The y -axis is the negative base 10 log of the p -value each probe associated with Interstitial Fibrosis

    Article Snippet: The bisulfite conversion efficiency was calculated using the bisulfite conversion control probes, based on Illumina guidelines.

    Techniques: Methylation, Genome Wide

    Replication of the association between cytosine methylation and intersistial fibrosis Of the 203 probes significantly associated with interstitial fibrosis (FDR < 0.05) in the primary dataset, 174 probes were assessed in the replication data set. 29 probes were excluded due to poor data quality. In total 65 of 174 probes were associated with interstitial fibrosis in the replication data set ( p -value < 0.05). All probes had directional consistency of methylation change. The primary data set and replication data set were then combined to reassess for probes significantly associated with interstitial fibrosis (FDR < 0.05). All associations were determined by linear regression models adjusted for age, gender, race, diabetes, hypertension, batch, bisulfite conversion, and degree of lymphocytic infiltrate on histology. Overall, 65 methylation probes associated with interstitial fibrosis were replicated

    Journal: Nature Communications

    Article Title: Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

    doi: 10.1038/s41467-019-10378-8

    Figure Lengend Snippet: Replication of the association between cytosine methylation and intersistial fibrosis Of the 203 probes significantly associated with interstitial fibrosis (FDR < 0.05) in the primary dataset, 174 probes were assessed in the replication data set. 29 probes were excluded due to poor data quality. In total 65 of 174 probes were associated with interstitial fibrosis in the replication data set ( p -value < 0.05). All probes had directional consistency of methylation change. The primary data set and replication data set were then combined to reassess for probes significantly associated with interstitial fibrosis (FDR < 0.05). All associations were determined by linear regression models adjusted for age, gender, race, diabetes, hypertension, batch, bisulfite conversion, and degree of lymphocytic infiltrate on histology. Overall, 65 methylation probes associated with interstitial fibrosis were replicated

    Article Snippet: The bisulfite conversion efficiency was calculated using the bisulfite conversion control probes, based on Illumina guidelines.

    Techniques: Methylation

    Progression model with top probes associated with gene expression changes

    Journal: Nature Communications

    Article Title: Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

    doi: 10.1038/s41467-019-10378-8

    Figure Lengend Snippet: Progression model with top probes associated with gene expression changes

    Article Snippet: The bisulfite conversion efficiency was calculated using the bisulfite conversion control probes, based on Illumina guidelines.

    Techniques: Gene Expression, Methylation